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CCL25 mediates the localization of recently activated CD8αβ+ lymphocytes to the small-intestinal mucosa
Marcus Svensson, … , Gabriel Márquez, William W. Agace
Marcus Svensson, … , Gabriel Márquez, William W. Agace
Published October 15, 2002
Citation Information: J Clin Invest. 2002;110(8):1113-1121. https://doi.org/10.1172/JCI15988.
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Article Aging

CCL25 mediates the localization of recently activated CD8αβ+ lymphocytes to the small-intestinal mucosa

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Abstract

Research Article

Authors

Marcus Svensson, Jan Marsal, Anna Ericsson, Laura Carramolino, Therese Brodén, Gabriel Márquez, William W. Agace

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Figure 2

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Regulation of CCR9 expression on antigen-specific CD8αβ+ lymphocytes fol...
Regulation of CCR9 expression on antigen-specific CD8αβ+ lymphocytes following activation in vivo. (a) OT-1 (Ly5.2+) cells were injected into C57BL/6J-Ly5.1 mice, and their expression of CCR9 was determined by flow cytometry 3 days after intraperitoneal OVA administration. Numbers represent the percentage of OT-1 cells that are CCR9+ with background staining removed. Results are from one representative experiment of nine (MLN), seven (PLN), and two (spleen) experiments performed. (b) OT-1 cells from the MLNs of OVA-treated mice respond to CCL25. MLN and PLN lymphocytes were isolated 3 days after intraperitoneal administration of OVA, and the ability of OT-1 cells and endogenous CD8αβ+ lymphocytes to migrate to CCL25 (250 nM) was determined. Results are the mean ± SEM of four experiments with three mice per experiment. *P < 0.005.

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