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Usage Information

Metabolic changes in aging humans: current evidence and therapeutic strategies
Allyson K. Palmer, Michael D. Jensen
Allyson K. Palmer, Michael D. Jensen
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Metabolic changes in aging humans: current evidence and therapeutic strategies

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Abstract

Aging and metabolism are inextricably linked, and many age-related changes in body composition, including increased central adiposity and sarcopenia, have underpinnings in fundamental aging processes. These age-related changes are further exacerbated by a sedentary lifestyle and can be in part prevented by maintenance of activity with aging. Here we explore the age-related changes seen in individual metabolic tissues — adipose, muscle, and liver — as well as globally in older adults. We also discuss the available evidence for therapeutic interventions such as caloric restriction, resistance training, and senolytic and senomorphic drugs to maintain healthy metabolism with aging, focusing on data from human studies.

Authors

Allyson K. Palmer, Michael D. Jensen

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Usage data is cumulative from July 2025 through July 2026.

Usage JCI PMC
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PDF 1,369 1,337
Figure 971 3
Citation downloads 311 0
Totals 16,267 28,142
Total Views 44,409

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ISSN: 0021-9738 (print), 1558-8238 (online)

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