Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
I. Sadaf Farooqi, … , Alex M. DePaoli, Stephen O’Rahilly
I. Sadaf Farooqi, … , Alex M. DePaoli, Stephen O’Rahilly
Published October 15, 2002
Citation Information: J Clin Invest. 2002;110(8):1093-1103. https://doi.org/10.1172/JCI15693.
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Article Metabolism

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Abstract

Research Article

Authors

I. Sadaf Farooqi, Giuseppe Matarese, Graham M. Lord, Julia M. Keogh, Elizabeth Lawrence, Chizo Agwu, Veronica Sanna, Susan A. Jebb, Francesco Perna, Silvia Fontana, Robert I. Lechler, Alex M. DePaoli, Stephen O’Rahilly

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Figure 3

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Leptin therapy results in pubertal development at an appropriate develop...
Leptin therapy results in pubertal development at an appropriate developmental age. (a) Pulsatile secretion of LH and FSH in child A after 12 and 24 months of r-metHuLeptin therapy. (b) No pulsatile secretion after 12 months of treatment in child B.