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Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets
Kathrin Maedler, … , Philippe A. Halban, Marc Y. Donath
Kathrin Maedler, … , Philippe A. Halban, Marc Y. Donath
Published September 15, 2002
Citation Information: J Clin Invest. 2002;110(6):851-860. https://doi.org/10.1172/JCI15318.
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Article Endocrinology

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

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Abstract

Research Article

Authors

Kathrin Maedler, Pavel Sergeev, Frédéric Ris, José Oberholzer, Helen I. Joller-Jemelka, Giatgen A. Spinas, Nurit Kaiser, Philippe A. Halban, Marc Y. Donath

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Figure 6

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IL-1Ra and PDTC restore glucose-stimulated insulin secretion in human is...
IL-1Ra and PDTC restore glucose-stimulated insulin secretion in human islets exposed to high glucose. Islets were cultured on extracellular matrix–coated dishes for 4 days in 5.5 and 33.3 mM glucose (control) or with IL-1Ra, PDTC, and IL-1β in combination or individually. (a and c) Basal and stimulated insulin secretion during successive 1-hour incubations at 3.3 (basal) and 16.7 (stimulated) mM glucose following the 4-day culture period. (b) Insulin content. Data are represented as mean ± SEM of three experiments from three separate donors. In each experiment, the data were collected from three plates per treatment. *P < 0.01 compared with islets cultured in 5.5 mM glucose alone. **P < 0.01 compared with islets cultured in 33.3 mM glucose alone. ***P < 0.01 compared with islets cultured in 5.5 mM glucose plus IL-1β.
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