Groups of six Lewis rats were injected with MBPp87–99/CFA (a) and MBPp68–86/CFA (b) to induce active EAE, or with P2p57–81/CFA to induce active EAN (c). Just after the onset of each disease (12, 10, and 10 days, respectively) these rats were administered (intravenously) 3 × 106 EL1 or RL1 activated line cells. An observer blind to the experimental protocol monitored clinical manifestation of disease. Mean EAE score ± SE of six rats per group is shown.