(a–d) Thirteen days after immunization with MBPp87–99/CFA to induce active EAE, the lower lumbar region of the spinal cord of EAE rats that were not subjected to soluble peptide therapy (b), subjected to therapy with soluble MBPp68–86 (c), or subjected to therapy with soluble MBPp68–86, and then with neutralizing Ab’s to IL-10 (d), were evaluated for histological scores of EAE in comparison with spinal cord sections from naive Lewis rats of comparable age to the experimental rats (a). Each section (except for control naive rats) represents 12 sections from three rats that were analyzed by an observer blind to experimental procedure. The full analysis of these samples is specified in the text. Hematoxylin and eosin–stained sections are shown at ×10.