T cell homeostatic proliferation elicits effective antitumor autoimmunity
Wolfgang Dummer, Andreas G. Niethammer, Roberto Baccala, Brian R. Lawson, Norbert Wagner, Ralph A. Reisfeld, Argyrios N. Theofilopoulos
Wolfgang Dummer, Andreas G. Niethammer, Roberto Baccala, Brian R. Lawson, Norbert Wagner, Ralph A. Reisfeld, Argyrios N. Theofilopoulos
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T cell homeostatic proliferation elicits effective antitumor autoimmunity

Abstract

Research Article

Authors

Wolfgang Dummer, Andreas G. Niethammer, Roberto Baccala, Brian R. Lawson, Norbert Wagner, Ralph A. Reisfeld, Argyrios N. Theofilopoulos

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Figure 1

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Inhibition of melanoma growth by homeostatic T cell proliferation. (a) N...
Inhibition of melanoma growth by homeostatic T cell proliferation. (a) Nonirradiated (circles) or sublethally irradiated (squares) C57BL/6 mice were challenged subcutaneously with 5 × 105 B78D14 melanoma cells. Groups of irradiated mice were transfused with 5 × 106 (inverted triangles) or 5 × 107 (triangles) syngeneic B6.PL LN cells. Means and standard deviation of tumor growth are indicated (all groups, n = 7). (b) Proliferation profiles of gated Thy1.1+CD4+ and Thy1.1+CD4– (CD8+) cells in secondary lymphoid organs shown as CFSE histograms. Upper panel: nonirradiated C57BL/6 mice (Thy1.2+) transfused with 107 B6.PL (Thy1.1+) cells; middle panel: C57BL/6 mice irradiated and transfused with 5 × 106 B6.PL LN cells; lower panel: C57BL/6 mice irradiated and transfused with 5 × 107 B6.PL LN cells. FACS dot plots of host lymphoid organs are depicted to the right. (c) Total number of proliferating (one or more cell divisions) donor CD4+ and CD8+ cells in C57BL/6 recipients of 5 × 106 or 5 × 107 B6.PL LN cells calculated from data presented in b.