In vivo inflammatory response in Plg/pCPB mice. A thioglycollate inflammation model was used in which mice (n = 7 per group) were injected intraperitoneally with 0.5 ml of a 4% Brewer thioglycollate solution. Mice were sacrificed, the peritoneal cavity exposed, and the exudate containing leukocytes was collected and counted. (a) Resident leukocyte levels in the peritoneum among the different Plg/pCPB genotypes at time 0 (uninjected mice). Open bars, pCPB genotypes in a Plg+/– background. (b) Total leukocyte levels in Plg transgenic mice 72 hours after thioglycollate injection. *P < 0.0001 vs. Plg+/+. Statistical analysis was performed by t test. (c) Total leukocyte levels in Plg+/–/pCPB transgenic mice 72 hours after thioglycollate injection. *P = 0.0004 vs. pCPB+/+ by ANOVA. No significant difference was observed between Plg+/–/pCPB+/– and Plg+/–/pCPB–/– mice (P = 0.1722) by t test.