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Heparin’s anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins
Lianchun Wang, … , Ajit Varki, Jeffrey D. Esko
Lianchun Wang, … , Ajit Varki, Jeffrey D. Esko
Published July 1, 2002
Citation Information: J Clin Invest. 2002;110(1):127-136. https://doi.org/10.1172/JCI14996.
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Article Vascular biology

Heparin’s anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins

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Abstract

Research Article

Authors

Lianchun Wang, Jillian R. Brown, Ajit Varki, Jeffrey D. Esko

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Figure 6

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Inhibition of thioglycollate-induced peritoneal inflammation. (a) Hepari...
Inhibition of thioglycollate-induced peritoneal inflammation. (a) Heparin and the various analogs at 0.5 (gray bars) or 1.25 mg per mouse (black bars) were injected intravenously 5 minutes after thioglycollate was injected intraperitoneally. The number of Gr-1–positive granulocytes in the peritoneal cavity was quantitated after 3 hours (see Methods). *Significant difference in neutrophil counts in the control mice that received standard heparin versus those injected with the indicated heparin derivatives. (b) Wild-type C57BL/6 and selectin-deficient mice were injected with heparin (0.5 mg) and thioglycollate. *Significant difference in neutrophil counts in mice treated with heparin (black bars) versus control mice that received only saline (gray bars). Each bar represents the average value ± SD; n = 5–10.
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