@article{10.1172/JCI143380, author = {Manish Sagar AND Katherine Reifler AND Michael Rossi AND Nancy S. Miller AND Pranay Sinha AND Laura F. White AND Joseph P. Mizgerd}, journal = {The Journal of Clinical Investigation}, publisher = {The American Society for Clinical Investigation}, title = {Recent endemic coronavirus infection is associated with less-severe COVID-19}, year = {2021}, month = {1}, volume = {131}, url = {https://www.jci.org/articles/view/143380}, abstract = {Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal common cold, and these eCoVs share extensive sequence homology with human SARS coronavirus 2 (SARS-CoV-2). Here, we show that individuals with, as compared with those without, a recent documented infection with eCoV were tested at greater frequency for respiratory infections but had a similar rate of SARS-CoV-2 acquisition. Importantly, the patients with a previously detected eCoV had less-severe coronavirus disease 2019 (COVID-19) illness. Our observations suggest that preexisting immune responses against endemic human coronaviruses can mitigate disease manifestations from SARS-CoV-2 infection.}, number = {1}, doi = {10.1172/JCI143380}, url = {https://doi.org/10.1172/JCI143380}, }