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Usage Information

Helicobacter pylori: preying on SIVA for survival in the stomach
José B. Sáenz, Jason C. Mills
José B. Sáenz, Jason C. Mills
Published April 6, 2020
Citation Information: J Clin Invest. 2020;130(5):2183-2185. https://doi.org/10.1172/JCI135508.
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Commentary

Helicobacter pylori: preying on SIVA for survival in the stomach

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Abstract

Infection with the Gram-negative bacterium Helicobacter pylori remains the most important modifiable risk factor for the development of gastric cancer, a leading cause of cancer-related deaths worldwide. How the interactions between H. pylori and its host shape the gastric environment during chronic infection warrants further investigation. In this issue of the JCI, Palrasu et al. used human cell lines and mouse models to provide mechanistic insight into H. pylori’s ability to delay apoptosis in gastric epithelial cells by actively driving the degradation of a proapoptotic factor, SIVA1. Their findings suggest that promoting the survival of gastric epithelial cells has implications not only for H. pylori pathogenesis but for host tumorigenesis.

Authors

José B. Sáenz, Jason C. Mills

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