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Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival
David T. Denhardt, … , Dubravko Pavlin, Jeffrey S. Berman
David T. Denhardt, … , Dubravko Pavlin, Jeffrey S. Berman
Published May 1, 2001
Citation Information: J Clin Invest. 2001;107(9):1055-1061. https://doi.org/10.1172/JCI12980.
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Commentary

Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival

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Abstract

Authors

David T. Denhardt, Masaki Noda, Anthony W. O’Regan, Dubravko Pavlin, Jeffrey S. Berman

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Figure 2

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Pro- and anti-inflammatory actions of OPN in cell injury and infection. ...
Pro- and anti-inflammatory actions of OPN in cell injury and infection. The left side of the diagram summarizes proinflammatory and anti-inflammatory events believed to be regulated by OPN. The right side summarizes known or predicted events in the OPN-null mouse. The center illustrates the wounding of the epithelium or endothelium, which is followed by macrophage-mediated containment of an infecting agent and, finally, repair of the injury. MMP-2, matrix metalloproteinase 2; M, macrophage. See text for further details.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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