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Usage Information

Selective tissue targeting of synthetic nucleic acid drugs
Punit P. Seth, Michael Tanowitz, C. Frank Bennett
Punit P. Seth, Michael Tanowitz, C. Frank Bennett
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Review

Selective tissue targeting of synthetic nucleic acid drugs

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Abstract

Antisense oligonucleotides (ASOs) are chemically synthesized nucleic acid analogs designed to bind to RNA by Watson-Crick base pairing. Following binding to the targeted RNA, the ASO perturbs RNA function by promoting selective degradation of the targeted RNA, altering RNA intermediary metabolism, or disrupting function of the RNA. Most antisense drugs are chemically modified to enhance their pharmacological properties and for passive targeting of the tissues of therapeutic interest. Recent advances in selective tissue targeting have resulted in a newer generation of ASO drugs that are more potent and better tolerated than previous generations, spawning renewed interest in identifying selective ligands that enhance targeted delivery of ASOs to tissues.

Authors

Punit P. Seth, Michael Tanowitz, C. Frank Bennett

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Usage data is cumulative from August 2025 through August 2026.

Usage JCI PMC
Text version 1,890 212
PDF 340 62
Figure 444 1
Table 457 0
Citation downloads 176 0
Totals 3,307 275
Total Views 3,582
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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