TY - JOUR AU - Watanabe, Satoshi AU - Alexander, Michael AU - Misharin, Alexander V. AU - Budinger, G.R. Scott T1 - The role of macrophages in the resolution of inflammation PY - 2019/07/01/ AB - Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal tissue development, homeostasis, and repair of damaged tissue. Macrophage function is a sum of their ontogeny, the local environment in which they reside, and the type of injuries or pathogen to which they are exposed. In this Review, we discuss the role of macrophages in the restoration of tissue function after injury, highlighting important questions about how they respond to and modify the local microenvironment to restore homeostasis. JF - The Journal of Clinical Investigation JA - J Clin Invest SN - 0021-9738 DO - 10.1172/JCI124615 VL - 129 IS - 7 UR - https://doi.org/10.1172/JCI124615 SP - 2619 EP - 2628 PB - The American Society for Clinical Investigation ER -