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Reparative T lymphocytes in organ injury
Franco R. D’Alessio, … , Johanna T. Kurzhagen, Hamid Rabb
Franco R. D’Alessio, … , Johanna T. Kurzhagen, Hamid Rabb
Published July 1, 2019
Citation Information: J Clin Invest. 2019;129(7):2608-2618. https://doi.org/10.1172/JCI124614.
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Review Series

Reparative T lymphocytes in organ injury

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Abstract

Acute organ injuries such as acute cerebrovascular accidents, myocardial infarction, acute kidney injury, acute lung injury, and others are among the leading causes of death worldwide. Dysregulated or insufficient organ repair mechanisms limit restoration of homeostasis and contribute to chronic organ failure. Studies reveal that both humans and mice harness potent non-stem cells that are capable of directly or indirectly promoting tissue repair. Specific populations of T lymphocytes have emerged as important reparative cells with context-specific actions. These T cells can resolve inflammation and secrete reparative cytokines and growth factors as well as interact with other immune and stromal cells to promote the complex and active process of tissue repair. This Review focuses on the major populations of T lymphocytes known to mediate tissue repair, their reparative mechanisms, and the diseases in which they have been implicated. Elucidating and harnessing the mechanisms that promote the reparative functions of these T cells could greatly improve organ dysfunction after acute injury.

Authors

Franco R. D’Alessio, Johanna T. Kurzhagen, Hamid Rabb

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Figure 1

Roles for Treg subsets in repair.

Options: View larger image (or click on image) Download as PowerPoint
Roles for Treg subsets in repair.
Conventional Tregs, CD8+ Tregs, and TR...
Conventional Tregs, CD8+ Tregs, and TR1 cells can directly influence repair processes by secreting pro-repair mediators. Conventional Tregs and TR1 cells also regulate other immune processes at the site of injury.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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