Commentary 10.1172/JCI124177

ATAC-ing the mechanisms of renin regulation

Steven D. Crowley

Department of Medicine, Duke University, Durham, North Carolina, USA. Department of Medicine, Durham VA Medical Centers, Durham, North Carolina, USA.

Address correspondence to: Steven D. Crowley, Division of Nephrology, Department of Medicine, Durham VA, and Duke University Medical Centers, DUMC Box 103015, Durham, North Carolina 27710, USA. Phone: 919.684.9788; Email: steven.d.crowley@duke.edu.

Find articles by Crowley, S. in: JCI | PubMed | Google Scholar

First published October 2, 2018 - More info

Published in Volume 128, Issue 11 on November 1, 2018
J Clin Invest. 2018;128(11):4748–4750. https://doi.org/10.1172/JCI124177.
Copyright © 2018, American Society for Clinical Investigation

First published October 2, 2018 - Version history

Renin-expressing cells have been conserved through evolution and maintain blood pressure and fluid homeostasis. Lack of availability of tools to study the specifics of renin regulation has limited advances in this field. In the current issue of the Journal of Clinical Investigation, Martinez and colleagues used the genome-wide assessment of the chromatin status of cells and uncovered a unique set of super-enhancers that determine the identity of renin cells. The renin super-enhancers play a key role in the molecular memory of renin cell function, a mechanism at the core of preserving homeostasis.

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