Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Lung inflammatory injury and tissue repair (Jul 2023)
    • Immune Environment in Glioblastoma (Feb 2023)
    • Korsmeyer Award 25th Anniversary Collection (Jan 2023)
    • Aging (Jul 2022)
    • Next-Generation Sequencing in Medicine (Jun 2022)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Research letters
    • Letters to the editor
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Research letters
  • Letters to the editor
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI119840

Impaired flow-induced dilation in mesenteric resistance arteries from mice lacking vimentin.

D Henrion, F Terzi, K Matrougui, M Duriez, C M Boulanger, E Colucci-Guyon, C Babinet, P Briand, G Friedlander, P Poitevin, and B I Lévy

Institut National de la Santé et de la Recherche Médicale (INSERM) U 141, IFR 6 (Circulation-Lariboisière), Hôpital Lariboisière, Paris, France. daniel.henrion@inserm.lrb.ap-hop-paris.fr

Find articles by Henrion, D. in: JCI | PubMed | Google Scholar

Institut National de la Santé et de la Recherche Médicale (INSERM) U 141, IFR 6 (Circulation-Lariboisière), Hôpital Lariboisière, Paris, France. daniel.henrion@inserm.lrb.ap-hop-paris.fr

Find articles by Terzi, F. in: JCI | PubMed | Google Scholar

Institut National de la Santé et de la Recherche Médicale (INSERM) U 141, IFR 6 (Circulation-Lariboisière), Hôpital Lariboisière, Paris, France. daniel.henrion@inserm.lrb.ap-hop-paris.fr

Find articles by Matrougui, K. in: JCI | PubMed | Google Scholar

Institut National de la Santé et de la Recherche Médicale (INSERM) U 141, IFR 6 (Circulation-Lariboisière), Hôpital Lariboisière, Paris, France. daniel.henrion@inserm.lrb.ap-hop-paris.fr

Find articles by Duriez, M. in: JCI | PubMed | Google Scholar

Institut National de la Santé et de la Recherche Médicale (INSERM) U 141, IFR 6 (Circulation-Lariboisière), Hôpital Lariboisière, Paris, France. daniel.henrion@inserm.lrb.ap-hop-paris.fr

Find articles by Boulanger, C. in: JCI | PubMed | Google Scholar

Institut National de la Santé et de la Recherche Médicale (INSERM) U 141, IFR 6 (Circulation-Lariboisière), Hôpital Lariboisière, Paris, France. daniel.henrion@inserm.lrb.ap-hop-paris.fr

Find articles by Colucci-Guyon, E. in: JCI | PubMed | Google Scholar

Institut National de la Santé et de la Recherche Médicale (INSERM) U 141, IFR 6 (Circulation-Lariboisière), Hôpital Lariboisière, Paris, France. daniel.henrion@inserm.lrb.ap-hop-paris.fr

Find articles by Babinet, C. in: JCI | PubMed | Google Scholar

Institut National de la Santé et de la Recherche Médicale (INSERM) U 141, IFR 6 (Circulation-Lariboisière), Hôpital Lariboisière, Paris, France. daniel.henrion@inserm.lrb.ap-hop-paris.fr

Find articles by Briand, P. in: JCI | PubMed | Google Scholar

Institut National de la Santé et de la Recherche Médicale (INSERM) U 141, IFR 6 (Circulation-Lariboisière), Hôpital Lariboisière, Paris, France. daniel.henrion@inserm.lrb.ap-hop-paris.fr

Find articles by Friedlander, G. in: JCI | PubMed | Google Scholar

Institut National de la Santé et de la Recherche Médicale (INSERM) U 141, IFR 6 (Circulation-Lariboisière), Hôpital Lariboisière, Paris, France. daniel.henrion@inserm.lrb.ap-hop-paris.fr

Find articles by Poitevin, P. in: JCI | PubMed | Google Scholar

Institut National de la Santé et de la Recherche Médicale (INSERM) U 141, IFR 6 (Circulation-Lariboisière), Hôpital Lariboisière, Paris, France. daniel.henrion@inserm.lrb.ap-hop-paris.fr

Find articles by Lévy, B. in: JCI | PubMed | Google Scholar

Published December 1, 1997 - More info

Published in Volume 100, Issue 11 on December 1, 1997
J Clin Invest. 1997;100(11):2909–2914. https://doi.org/10.1172/JCI119840.
© 1997 The American Society for Clinical Investigation
Published December 1, 1997 - Version history
View PDF
Abstract

The intermediate filament vimentin might play a key role in vascular resistance to mechanical stress. We investigated the responses to pressure (tensile stress) and flow (shear stress) of mesenteric resistance arteries perfused in vitro from vimentin knockout mice. Arteries were isolated from homozygous (Vim-/-, n = 14) or heterozygous vimentin-null mice (Vim+/-, n = 5) and from wild-type littermates (Vim+/+, n = 9). Passive arterial diameter (175+/-15 micron in Vim+/+ at 100 mmHg) and myogenic tone were not affected by the absence of vimentin. Flow-induced (0-150 microl/min) dilation (e. g., 19+/-3 micron dilation at 150 mmHg in Vim+/+) was significantly attenuated in Vim-/- mice (13+/-2 micron dilation, P < 0.01). Acute blockade of nitric oxide synthesis (NG-nitro- L-arginine, 10 microM) significantly decreased flow-induced dilation in both groups, whereas acute blockade of prostaglandin synthesis (indomethacin, 10 microM) had no significant effect. Mean blood pressure, in vivo mesenteric blood flow and diameter, and mesenteric artery media thickness or media to lumen ratio were not affected by the absence of vimentin. Thus, the absence of vimentin decreased selectively the response of resistance arteries to flow, suggesting a role for vimentin in the mechanotransduction of shear stress.

Version history
  • Version 1 (December 1, 1997): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2023 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts