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Research Article Free access | 10.1172/JCI119734

Targeted disruption of the beta-chemokine receptor CCR1 protects against pancreatitis-associated lung injury.

C Gerard, J L Frossard, M Bhatia, A Saluja, N P Gerard, B Lu, and M Steer

Ina Sue Perlmutter Laboratory, Children's Hospital, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School and the Center for Blood Research, Boston, Massachusetts 02115, USA.

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Ina Sue Perlmutter Laboratory, Children's Hospital, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School and the Center for Blood Research, Boston, Massachusetts 02115, USA.

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Ina Sue Perlmutter Laboratory, Children's Hospital, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School and the Center for Blood Research, Boston, Massachusetts 02115, USA.

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Ina Sue Perlmutter Laboratory, Children's Hospital, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School and the Center for Blood Research, Boston, Massachusetts 02115, USA.

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Ina Sue Perlmutter Laboratory, Children's Hospital, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School and the Center for Blood Research, Boston, Massachusetts 02115, USA.

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Ina Sue Perlmutter Laboratory, Children's Hospital, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School and the Center for Blood Research, Boston, Massachusetts 02115, USA.

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Ina Sue Perlmutter Laboratory, Children's Hospital, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School and the Center for Blood Research, Boston, Massachusetts 02115, USA.

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Published October 15, 1997 - More info

Published in Volume 100, Issue 8 on October 15, 1997
J Clin Invest. 1997;100(8):2022–2027. https://doi.org/10.1172/JCI119734.
© 1997 The American Society for Clinical Investigation
Published October 15, 1997 - Version history
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Abstract

beta-Chemokines and their receptors mediate the trafficking and activation of a variety of leukocytes including the lymphocyte and macrophage. An array of no less than eight beta-chemokine receptors has been identified, four of which are capable of recognizing the chemokines MIP1alpha and RANTES. Genetic deletion of one of the MIP1alpha and RANTES receptors, CCR5, is associated with protection from infection with HIV-1 in humans, while deletion of the ligand MIP1alpha protects against Coxsackie virus-associated myocarditis. In this report we show that the deletion of another receptor for MIP1alpha and RANTES, the CCR1 receptor, is associated with protection from pulmonary inflammation secondary to acute pancreatitis in the mouse. The protection from lung injury is associated with decreased levels of TNF-alpha in a temporal sequence indicating that the activation of the CCR1 receptor is an early event in the systemic inflammatory response syndrome.

Version history
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