Advertisement

Research Article Free access | 10.1172/JCI115572

Autoimmune disease of the ovary induced by a ZP3 peptide from the mouse zona pellucida.

S H Rhim, S E Millar, F Robey, A M Luo, Y H Lou, T Yule, P Allen, J Dean, and K S Tung

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

Find articles by Rhim, S. in: JCI | PubMed | Google Scholar

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

Find articles by Millar, S. in: JCI | PubMed | Google Scholar

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

Find articles by Robey, F. in: JCI | PubMed | Google Scholar

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

Find articles by Luo, A. in: JCI | PubMed | Google Scholar

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

Find articles by Lou, Y. in: JCI | PubMed | Google Scholar

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

Find articles by Yule, T. in: JCI | PubMed | Google Scholar

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

Find articles by Allen, P. in: JCI | PubMed | Google Scholar

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

Find articles by Dean, J. in: JCI | PubMed | Google Scholar

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

Find articles by Tung, K. in: JCI | PubMed | Google Scholar

First published January 1, 1992 - More info

Published in Volume 89, Issue 1 on January 1, 1992
J Clin Invest. 1992;89(1):28–35. https://doi.org/10.1172/JCI115572.
© 1992 The American Society for Clinical Investigation
First published January 1, 1992 - Version history
Abstract

We describe a novel experimental system in mice for the study of ovarian autoimmune disease, a condition encountered in women with premature ovarian failure. The ovarian autoimmune disease is induced in B6AF1 mice by a 15-amino acid peptide (Cys-Ser-Asn-Ser-Ser-Ser-Ser-Gln-Phe-Gln-Ile-His-Gly-Pro-Arg) from mouse ZP3, the sperm-binding component of the zona pellucida that surrounds growing and mature oocytes. Whereas the peptide induces both T cell and antibody responses, adoptive transfer of CD4+ T cell lines derived from affected animals causes oophoritis without observable antibodies to the zona pellucida peptide. The primacy of the T cell response in the pathogenesis of disease is further substantiated by defining oophoritogenic peptides as small as eight amino acids (Asn-Ser-Ser-Ser-Ser-Gln-Phe-Gln) that do not elicit an antibody response to the full-length ZP3 peptide. The identification of a well characterized peptide as a causative agent of autoimmune oophoritis should facilitate understanding of the pathogenesis of this T cell-mediated autoimmune disease. Because the proteins of the zona pellucida are conserved among mammals (the mouse and human ZP3 proteins are 67% identical), this murine model may lead to better understanding of the pathogenesis of human autoimmune oophoritis.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (January 1, 1992): No description
Advertisement
Advertisement