Usage Information

Acetylcholinesterase and butyrylcholinesterase genes coamplify in primary ovarian carcinomas.
H Zakut, G Ehrlich, A Ayalon, C A Prody, G Malinger, S Seidman, D Ginzberg, R Kehlenbach, H Soreq
H Zakut, G Ehrlich, A Ayalon, C A Prody, G Malinger, S Seidman, D Ginzberg, R Kehlenbach, H Soreq
View: Text | PDF
Research Article

Acetylcholinesterase and butyrylcholinesterase genes coamplify in primary ovarian carcinomas.

Abstract

The genes for acetylcholinesterase (ACHE) and butyrylcholinesterase (CHE) are expressed in multiple tumor tissues, including ovarian carcinomas. Both CHE and ACHE genes coamplify in leukemias. To examine the relationship of gene amplification to the expression of these genes in tumors, ACHE and CHE genes and their expression were studied in primary ovarian carcinomas. DNA blot hybridization demonstrated a significant amplification and mutagenesis of both genes in 6 of 11 malignant tumors studied. This was greater or of the same order of magnitude as the amplification of the oncogenes c-rafi, v-sis, and c-fes in these tumors. No amplification was found in normal ovarian tissues or benign ovarian cysts. Xenopus oocyte microinjections, blot and in situ hybridizations, and immuno- and cytochemical staining revealed translatable CHEmRNA and its active protein product in discrete tumor foci. The frequent coamplification in ovarian carcinomas of ACHE and CHE genes implicates cholinesterases in neoplastic growth and/or proliferation.

Authors

H Zakut, G Ehrlich, A Ayalon, C A Prody, G Malinger, S Seidman, D Ginzberg, R Kehlenbach, H Soreq

×

Usage data is cumulative from June 2025 through June 2026.

Usage JCI PMC
Text version 417 10
PDF 219 7
Figure 0 2
Scanned page 827 12
Citation downloads 159 0
Totals 1,622 31
Total Views 1,653
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement