Human embryonic hemopoiesis. Kinetics of progenitors and precursors underlying the yolk sac----liver transition.

G Migliaccio; A R Migliaccio; S Petti; F Mavilio; G Russo; D Lazzaro; U Testa; M Marinucci; C Peschle

doi:10.1172/JCI112572

Find articles by Migliaccio, G. in: JCI | PubMed | Google Scholar

Find articles by Migliaccio, A. in: JCI | PubMed | Google Scholar

Find articles by Petti, S. in: JCI | PubMed | Google Scholar

Find articles by Mavilio, F. in: JCI | PubMed | Google Scholar

Find articles by Russo, G. in: JCI | PubMed | Google Scholar

Find articles by Lazzaro, D. in: JCI | PubMed | Google Scholar

Find articles by Testa, U. in: JCI | PubMed | Google Scholar

Find articles by Marinucci, M. in: JCI | PubMed | Google Scholar

Find articles by Peschle, C. in: JCI | PubMed | Google Scholar

Published in Volume 78, Issue 1 on July 1, 1986
J Clin Invest. 1986;78(1):51–60. https://doi.org/10.1172/JCI112572.
© 1986 The American Society for Clinical Investigation

Published July 1, 1986 - Version history

Human embryonic development involves transition from yolk sac (YS) to liver (L) hemopoiesis. We report the identification of pluripotent, erythroid, and granulo-macrophage progenitors in YS, L, and blood from human embryos. Furthermore, comprehensive studies are presented on the number of hemopoietic progenitors and precursors, as well as of other cell types, in YS, L, and blood at precisely sequential stages in embryos and early fetuses (i.e., at 4.5-8 wk and 9-10 wk postconception, respectively). Our results provide circumstantial support to a monoclonal hypothesis for human embryonic hemopoiesis, based on migration of stem and early progenitor cells from a generation site (YS) to a colonization site (L) via circulating blood. The YS----L transition is associated with development of the differentiation program in proliferating stem cells: their erythroid progeny shows, therefore, parallel switches of multiple parameters, e.g., morphology (megaloblasts----macrocytes) and globin expression (zeta----alpha, epsilon----gamma).

Images.