Linkage Analysis between the Major Histocompatibility System and Insulin-dependent Diabetes in Families with Patients in Two Consecutive Generations

• Text
• PDF

Abstract

We have histocompatibility (HLA) genotyped 28 families with insulin-dependent diabetics in two or more consecutive generations, usually parent and child. This strategy of ascertainment was used to maximize the likelihood of obtaining a homogeneous type of disease within a family, and an autosomal dominant mode of inheritance. 76 diabetics and 169 nondiabetics were studied in these families.

Authors

Jose Barbosa, M. Myra Chern, V. Elving Anderson, Harriet Noreen, Sandra Johnson, Nancy Reinsmoen, Ronald McCarty, Richard King, Leonard Greenberg