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Research Article Free access | 10.1172/JCI109638

Developmental changes in glucose transport of guinea pig erythrocytes.

T Kondo and E Beutler

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Published January 1, 1980 - More info

Published in Volume 65, Issue 1 on January 1, 1980
J Clin Invest. 1980;65(1):1–4. https://doi.org/10.1172/JCI109638.
© 1980 The American Society for Clinical Investigation
Published January 1, 1980 - Version history
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Abstract

The developmental changes in the capacity for D-glucose transport of guinea pig erythrocyte membranes were compared to alterations in the electrophoretic pattern of erythrocyte membrane components. Guinea pig erythrocytes lose their D-glucose carrier functions during development. Good correlation was observed between the loss of glucose uptake and apparent decrease of the zone 4.5 of Coomassie Blue-stained membrane proteins on electrophoresis. Reconstitution of membrane preparations in liposomes resulted in a parallel change in the D-glucose uptake and D-glucose penetration of intact erythrocytes. This suggests that the decrease of D-glucose transport capacity during development is caused by the loss of one or more protein components from the erythrocyte membranes.

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