Effect of Hypersensitivity on Protein Uptake Across the Air-Blood Barrier of Isolated Rabbit Lungs

• Text
• PDF

Abstract

In previous studies with isolated perfused rabbit lungs, we observed that human serum albumin (HSA) and ovalbumin, introduced into the isolated lungs as an aerosol, entered the pulmonary circulation antigenically intact. The “inhaled” proteins were also broken down in the lung. When lungs from animals immunized with one protein inhaled the two proteins simultaneously, absorption of intact antigen was specifically reduced, and there was a nonspecific increase in the appearance of metabolites of both proteins in the blood.

Authors

Janet F. Braley, Laurence B. Peterson, Christopher A. Dawson, Vernon L. Moore