Studies of Immune Functions of Patients with Systemic Lupus Erythematosus: COMPLEMENT-DEPENDENT IMMUNOGLOBULIN M ANTI-THYMUS-DERIVED CELL ANTIBODIES PREFERENTIALLY INACTIVATE SUPPRESSOR CELLS

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Abstract

Patients with systemic lupus erythematosus (SLE) produce excessive amounts of autoantibodies. It has also been demonstrated in several systems that such patients have a relative loss of suppressor thymus-derived (T) cells that inhibit the immune response. This loss of suppressor cells has been suggested as one of the causes of the excessive production of antibodies in patients with SLE.

Authors

Tsuyoshi Sakane, Alfred D. Steinberg, J. Patton Reeves, Ira Green