Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Immune Environment in Glioblastoma (Feb 2023)
    • Korsmeyer Award 25th Anniversary Collection (Jan 2023)
    • Aging (Jul 2022)
    • Next-Generation Sequencing in Medicine (Jun 2022)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • Circadian Rhythm (Oct 2021)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Research letters
    • Letters to the editor
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Research letters
  • Letters to the editor
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI106876

Effects of Dibutyryl Cyclic Adenosine 3′,5′-Monophosphate and Parathyroid Extract on Calcium and Phosphorus Metabolism in Hypoparathyroidism and Pseudohypoparathyroidism

Norman H. Bell, Susan Avery, Tushar Sinha, Charles M. Clark Jr., Donald O. Allen, and Conrad Johnston Jr.

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Medicine, Veterans Administration Hospital, Indianapolis, Indiana 46202

Department of Biochemistry, Veterans Administration Hospital, Indianapolis, Indiana 46202

Department of Pharmacology, Veterans Administration Hospital, Indianapolis, Indiana 46202

Find articles by Bell, N. in: JCI | PubMed | Google Scholar

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Medicine, Veterans Administration Hospital, Indianapolis, Indiana 46202

Department of Biochemistry, Veterans Administration Hospital, Indianapolis, Indiana 46202

Department of Pharmacology, Veterans Administration Hospital, Indianapolis, Indiana 46202

Find articles by Avery, S. in: JCI | PubMed | Google Scholar

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Medicine, Veterans Administration Hospital, Indianapolis, Indiana 46202

Department of Biochemistry, Veterans Administration Hospital, Indianapolis, Indiana 46202

Department of Pharmacology, Veterans Administration Hospital, Indianapolis, Indiana 46202

Find articles by Sinha, T. in: JCI | PubMed | Google Scholar

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Medicine, Veterans Administration Hospital, Indianapolis, Indiana 46202

Department of Biochemistry, Veterans Administration Hospital, Indianapolis, Indiana 46202

Department of Pharmacology, Veterans Administration Hospital, Indianapolis, Indiana 46202

Find articles by Clark, C. in: JCI | PubMed | Google Scholar

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Medicine, Veterans Administration Hospital, Indianapolis, Indiana 46202

Department of Biochemistry, Veterans Administration Hospital, Indianapolis, Indiana 46202

Department of Pharmacology, Veterans Administration Hospital, Indianapolis, Indiana 46202

Find articles by Allen, D. in: JCI | PubMed | Google Scholar

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana 46202

Department of Medicine, Veterans Administration Hospital, Indianapolis, Indiana 46202

Department of Biochemistry, Veterans Administration Hospital, Indianapolis, Indiana 46202

Department of Pharmacology, Veterans Administration Hospital, Indianapolis, Indiana 46202

Find articles by Johnston, C. in: JCI | PubMed | Google Scholar

Published April 1, 1972 - More info

Published in Volume 51, Issue 4 on April 1, 1972
J Clin Invest. 1972;51(4):816–823. https://doi.org/10.1172/JCI106876.
© 1972 The American Society for Clinical Investigation
Published April 1, 1972 - Version history
View PDF
Abstract

It has been proposed previously that the metabolic defect in pseudohypoparathyroidism which accounts for parathyroid hormone unresponsiveness is an absence or abnormal form of the adenyl cyclase system in kidney and presumably in bone. To determine whether there is an associated defect in the response mechanism to cyclic adenosine 3′,5′-monophosphate (cyclic AMP), the effects of parathyroid extract (PTE), and dibutyryl cyclic AMP were compared in patients with either surgical hypoparathyroidism or pseudohypoparathyroidism. PTE and dibutyryl cyclic AMP both increased serum and urinary calcium, lowered the serum phosphorus, and increased urinary phosphorus in patients with hypoparathyroidism. PTE also increased urinary cyclic AMP in these patients. PTE increased serum and urinary calcium and urinary phosphorus but did not alter serum phosphorus or urinary cyclic AMP in the patients with pseudohypoparathyroidism. Dibutyryl cyclic AMP increased the serum and urinary calcium, lowered the serum phosphorus, and increased urinary phosphorus in all the patients with pseudohypoparathyroidism. The results indicate that (a) dibutyryl cyclic AMP can reproduce the effects of parathyroid hormone on calcium and phosphorus metabolism in man, (b) the response mechanism to cyclic AMP appears to be intact in pseudohypoparathyroidism, and (c) PTE apparently produces some of its characteristic effects on calcium and phosphorus metabolism in pseudohypoparathyroidism in the absence of an increase in urinary cyclic AMP.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 816
page 816
icon of scanned page 817
page 817
icon of scanned page 818
page 818
icon of scanned page 819
page 819
icon of scanned page 820
page 820
icon of scanned page 821
page 821
icon of scanned page 822
page 822
icon of scanned page 823
page 823
Version history
  • Version 1 (April 1, 1972): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2023 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts