The Renal Clearance of Amino Acids in Cystinuria

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Abstract

The renal clearance of cystine, lysine, ornithine, arginine, and glycine has been compared with the simultaneously determined glomerular filtration rate in nine cystinuric patients. Five were studied before and after stabilization on penicillamine therapy, two were studied only while taking penicillamine, and two were studied only in the absence of penicillamine administration. The renal clearances of cysteine-penicillamine and of penicillamine disulfide were also determined in the patients who were taking the drug.

Authors

J. C. Crawhall, E. F. Scowen, C. J. Thompson, R. W. E. Watts