Cellular sources of new pancreatic β cells and therapeutic implications for regenerative medicine
PA Halban - Nature cell biology, 2004 - nature.com
PA Halban
Nature cell biology, 2004•nature.comReplacing missing insulin-producing β cells to treat diabetes is a major challenge for
regenerative medicine. A better understanding of β-cell embryogenesis and regeneration in
adult life is needed to devise means to derive these specialized cells in sufficiently large
numbers from stem or precursor cells. It is also critical to ensure that any surrogate or
regenerated β cells have perfectly regulated insulin production, which is essential for
physiological glucose homeostasis.
regenerative medicine. A better understanding of β-cell embryogenesis and regeneration in
adult life is needed to devise means to derive these specialized cells in sufficiently large
numbers from stem or precursor cells. It is also critical to ensure that any surrogate or
regenerated β cells have perfectly regulated insulin production, which is essential for
physiological glucose homeostasis.
Abstract
Replacing missing insulin-producing β cells to treat diabetes is a major challenge for regenerative medicine. A better understanding of β-cell embryogenesis and regeneration in adult life is needed to devise means to derive these specialized cells in sufficiently large numbers from stem or precursor cells. It is also critical to ensure that any surrogate or regenerated β cells have perfectly regulated insulin production, which is essential for physiological glucose homeostasis.
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