Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus

JC Voltarelli, CEB Couri, ABPL Stracieri, MC Oliveira… - Jama, 2007 - jamanetwork.com
ContextType 1 diabetes mellitus (DM) results from a cell-mediated autoimmune attack
against pancreatic beta cells. Previous animal and clinical studies suggest that moderate
immunosuppression in newly diagnosed type 1 DM can prevent further loss of insulin
production and can reduce insulin needs. ObjectiveTo determine the safety and metabolic
effects of high-dose immunosuppression followed by autologous nonmyeloablative
hematopoietic stem cell transplantation (AHST) in newly diagnosed type 1 DM. Design …