Heart failure and protein quality control

X Wang, J Robbins - Circulation research, 2006 - Am Heart Assoc
X Wang, J Robbins
Circulation research, 2006Am Heart Assoc
The heart is constantly under mechanical, metabolic, and thermal stress, even at baseline
physiological conditions, and cardiac stress may increase as a result of environmental or
intrinsic pathological insults. Cardiomyocytes are continuously challenged to efficiently and
properly fold nascent polypeptides, traffic them to their appropriate cellular locations, and
keep them from denaturing in the face of normal and pathological stimuli. Because
deployment of misfolded or unfolded proteins can be disastrous, cells, in general, and …
The heart is constantly under mechanical, metabolic, and thermal stress, even at baseline physiological conditions, and cardiac stress may increase as a result of environmental or intrinsic pathological insults. Cardiomyocytes are continuously challenged to efficiently and properly fold nascent polypeptides, traffic them to their appropriate cellular locations, and keep them from denaturing in the face of normal and pathological stimuli. Because deployment of misfolded or unfolded proteins can be disastrous, cells, in general, and cardiomyocytes, in particular, have developed a multilayered protein quality control system for maintaining proper protein conformation and for reorganizing and removing misfolded or aggregated polypeptides. Here, we examine recent data pointing to the importance of protein quality control in cardiac homeostasis and disease.
Am Heart Assoc