[HTML][HTML] Notch oncoproteins depend on γ-secretase/presenilin activity for processing and function
During normal development Notch receptor signaling is important in regulating numerous
cell fate decisions. Mutations that truncate the extracellular domain of Notch receptors can
cause aberrant signaling and promote unregulated cell growth. We have examined two
types of truncated Notch oncoproteins that arise from proviral insertion into the Notch4 gene
(Notch4/int-3) or a chromosomal translocation involving the Notch1 gene (TAN-1). Both
Notch4/int-3 and TAN-1 oncoproteins lack most or all of their ectodomain. Normal Notch …
cell fate decisions. Mutations that truncate the extracellular domain of Notch receptors can
cause aberrant signaling and promote unregulated cell growth. We have examined two
types of truncated Notch oncoproteins that arise from proviral insertion into the Notch4 gene
(Notch4/int-3) or a chromosomal translocation involving the Notch1 gene (TAN-1). Both
Notch4/int-3 and TAN-1 oncoproteins lack most or all of their ectodomain. Normal Notch …