[HTML][HTML] Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream …
KL Pierce, A Tohgo, S Ahn, ME Field, LM Luttrell… - Journal of Biological …, 2001 - ASBMB
" Transactivation" of epidermal growth factor receptors (EGFRs) in response to activation of
many G protein-coupled receptors (GPCRs) involves autocrine/paracrine shedding of
heparin-binding EGF (HB-EGF). HB-EGF shedding involves proteolytic cleavage of a
membrane-anchored precursor by incompletely characterized matrix metalloproteases. In
COS-7 cells, α 2A-adrenergic receptors (ARs) stimulate ERK phosphorylation via two distinct
pathways, a transactivation pathway that involves the release of HB-EGF and the EGFR and …
many G protein-coupled receptors (GPCRs) involves autocrine/paracrine shedding of
heparin-binding EGF (HB-EGF). HB-EGF shedding involves proteolytic cleavage of a
membrane-anchored precursor by incompletely characterized matrix metalloproteases. In
COS-7 cells, α 2A-adrenergic receptors (ARs) stimulate ERK phosphorylation via two distinct
pathways, a transactivation pathway that involves the release of HB-EGF and the EGFR and …