Ischemia/reperfusion (I/R) injury is a multifactorial process that affects graft function after liver
transplantation. An understanding of the mechanisms involved in I/R injury is essential for
the design of therapeutic strategies to improve the outcome of liver transplantation. The
generation of reactive oxygen species subsequent to reoxygenation inflicts tissue damage
and initiates a cascade of deleterious cellular responses leading to inflammation, cell death,
and ultimate organ failure. Increased experimental evidence has suggested that Kupffer …