[HTML][HTML] β3-adrenergic receptors on white and brown adipocytes mediate β3-selective agonist-induced effects on energy expenditure, insulin secretion, and food …
D Grujic, VS Susulic, ME Harper… - Journal of Biological …, 1997 - ASBMB
β3-Adrenergic receptors (β3-ARs) are expressed predominantly on white and brown
adipocytes, and acute treatment of mice with CL 316,243, a potent and highly selective β3-
AR agonist, produces a 2-fold increase in energy expenditure, a 50–100-fold increase in
insulin levels, and a 40–50% reduction in food intake. Recently, we generated gene
knockout mice lacking functional β3-ARs and demonstrated that each of these responses
were mediated exclusively by β3-ARs. However, the tissue site responsible for producing …
adipocytes, and acute treatment of mice with CL 316,243, a potent and highly selective β3-
AR agonist, produces a 2-fold increase in energy expenditure, a 50–100-fold increase in
insulin levels, and a 40–50% reduction in food intake. Recently, we generated gene
knockout mice lacking functional β3-ARs and demonstrated that each of these responses
were mediated exclusively by β3-ARs. However, the tissue site responsible for producing …