[HTML][HTML] Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein AI
ML Gruen, MR Plummer, W Zhang, KA Posey… - Journal of lipid …, 2005 - ASBMB
Obese mice without leptin (ob/ob) or the leptin receptor (db/db) have increased plasma HDL
levels and accumulate a unique lipoprotein referred to as LDL/HDL1. To determine the role
of apolipoprotein AI (apoA-I) in the formation and accumulation of LDL/HDL1, both ob/ob
and db/db mice were crossed onto an apoA-I-deficient (apoA-I−/−) background. Even though
the obese apoA-I−/− mice had an expected dramatic decrease in HDL levels, the LDL/HDL1
particle persisted. The cholesterol in this lipoprotein range was associated with both α-and β …
levels and accumulate a unique lipoprotein referred to as LDL/HDL1. To determine the role
of apolipoprotein AI (apoA-I) in the formation and accumulation of LDL/HDL1, both ob/ob
and db/db mice were crossed onto an apoA-I-deficient (apoA-I−/−) background. Even though
the obese apoA-I−/− mice had an expected dramatic decrease in HDL levels, the LDL/HDL1
particle persisted. The cholesterol in this lipoprotein range was associated with both α-and β …