[HTML][HTML] Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence
M Yasuda, P Theodorakis, T Subramanian… - Journal of Biological …, 1998 - ASBMB
Adenovirus E1B-19K and BCL-2 anti-apoptosis proteins interact with certain BCL-2 family
pro-apoptotic proteins. A conserved domain, BH3, present in these proteins is essential for
their pro-apoptotic activity and for heterodimerization with anti-apoptosis proteins. Cellular
protein BNIP3 (previously NIP3) interacts with E1B-19K, BCL-2, BCL-x L, and EBV-BHRF1.
BNIP3 contains a motif similar to the BH3 domain. Deletion of the BH3-like motif in BNIP3
abrogates its ability to heterodimerize with E1B-19K and BCL-x L. Substitution of the BH3 …
pro-apoptotic proteins. A conserved domain, BH3, present in these proteins is essential for
their pro-apoptotic activity and for heterodimerization with anti-apoptosis proteins. Cellular
protein BNIP3 (previously NIP3) interacts with E1B-19K, BCL-2, BCL-x L, and EBV-BHRF1.
BNIP3 contains a motif similar to the BH3 domain. Deletion of the BH3-like motif in BNIP3
abrogates its ability to heterodimerize with E1B-19K and BCL-x L. Substitution of the BH3 …