Epstein-Barr virus immunossuppression of innate immunity mediated by phagocytes

M Savard, J Gosselin - Virus research, 2006 - Elsevier
Epstein-Barr virus (EBV) is an oncogenic human herpesvirus that persistently infects
approximately 90% of the world's population. Such a remarkably sustained of viral infectivity
relies on EBV's ability to evade the host immune defenses. A crucial part of this anti-EBV
response is mediated by cytotoxic CD8+ T lymphocytes, which maintain a life-long control
over proliferating latently-infected B cells in order to prevent these from giving rise to
lymphomatous diseases. On the other hand, little has been done to assess the role of …