[HTML][HTML] A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate β-catenin-dependent signaling
SL Holmen, A Salic, CR Zylstra, MW Kirschner… - Journal of Biological …, 2002 - ASBMB
Wnt proteins initiate the canonical (β-catenin-regulated) signaling cascade by binding to
seven-transmembrane spanning receptors of the Frizzled (Fz) family together with the
coreceptors LRP5 and-6, members of the low density lipoprotein receptor-related protein
family (LRP). Several reports have shown physical and functional associations between
various Wnt, LRP, and Frizzled molecules; however, the underlying mechanisms for
selectivity remain poorly understood. We present data on a novel set of Wnt-Fz fusion …
seven-transmembrane spanning receptors of the Frizzled (Fz) family together with the
coreceptors LRP5 and-6, members of the low density lipoprotein receptor-related protein
family (LRP). Several reports have shown physical and functional associations between
various Wnt, LRP, and Frizzled molecules; however, the underlying mechanisms for
selectivity remain poorly understood. We present data on a novel set of Wnt-Fz fusion …