[HTML][HTML] Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance

N Kamei, K Tobe, R Suzuki, M Ohsugi… - Journal of biological …, 2006 - ASBMB
Adipose tissue expression and circulating concentrations of monocyte chemoattractant
protein-1 (MCP-1) correlate positively with adiposity. To ascertain the roles of MCP-1
overexpression in adipose, we generated transgenic mice by utilizing the adipocyte P2
(aP2) promoter (aP2-MCP-1 mice). These mice had higher plasma MCP-1 concentrations
and increased macrophage accumulation in adipose tissues, as confirmed by
immunochemical, flow cytometric, and gene expression analyses. Tumor necrosis factor-α …