Induced neurogenesis by endogeneous progenitor cells in the adult mammalian brain
E Chmielnicki, SA Goldman - Progress in Brain Research, 2002 - Elsevier
Neurodegenerative diseases are characterized by the gradual loss of mature functional
neuronal populations witbin the nervous system (Kowall et al., 1987; Cummings et al., 1998;
Jenner and Olanow, 1998). Mature neurons are postmitotic and hence incapable of self-
renewal, and spontaneous replacement of the dying neurons has not been reported in any
neurodegenerative disease or experimental model thereof. Nonetheless, the identification of
neural progenitor cells in both periventricular and parenchymal regions of the adult …
neuronal populations witbin the nervous system (Kowall et al., 1987; Cummings et al., 1998;
Jenner and Olanow, 1998). Mature neurons are postmitotic and hence incapable of self-
renewal, and spontaneous replacement of the dying neurons has not been reported in any
neurodegenerative disease or experimental model thereof. Nonetheless, the identification of
neural progenitor cells in both periventricular and parenchymal regions of the adult …