[HTML][HTML] Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes
AZ Zhao, MM Shinohara, D Huang, M Shimizu… - Journal of Biological …, 2000 - ASBMB
Although many effects of leptin are mediated through the central nervous system, leptin can
regulate metabolism through a direct action on peripheral tissues, such as fat and liver. We
show here that leptin, at physiological concentrations, acts through an intracellular signaling
pathway similar to that activated by insulin in isolated primary rat hepatocytes. This pathway
involves stimulation of phosphatidylinositol 3-kinase (PI3K) binding to insulin receptor
substrate-1 and insulin receptor substrate-2, activation of PI3K and protein kinase B (AKT) …
regulate metabolism through a direct action on peripheral tissues, such as fat and liver. We
show here that leptin, at physiological concentrations, acts through an intracellular signaling
pathway similar to that activated by insulin in isolated primary rat hepatocytes. This pathway
involves stimulation of phosphatidylinositol 3-kinase (PI3K) binding to insulin receptor
substrate-1 and insulin receptor substrate-2, activation of PI3K and protein kinase B (AKT) …