Fibrinogen biosynthesis is regulated under normal and pathophysiological conditions by the
constitutive, hormonal and cytokine-mediated mechanisms. As an acute-phase protein,
fibrinogen biosynthesis is regulated by glucocorticoids and cytokines. Recent studies iawe
defined glucococticoid-consensus sequences on the [beta]-chain promoter. The cytokine
mediating production of fibrinogen, originally termed leukocyte endogenous mediator and
hepatocyte stimulatory factor, has now been demonstrated to be derived from a single gene …