[HTML][HTML] Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases
BT Chua, K Guo, P Li - Journal of Biological Chemistry, 2000 - ASBMB
Caspases, a unique family of cysteine proteases involved in cytokine activation and in the
execution of apoptosis can be sub-grouped according to the length of their prodomain. Long
prodomain caspases such as caspase-8 and caspase-9 are believed to act mainly as
upstream caspases to cleave downstream short prodomain caspases such as caspases-3
and-7. We report here the identification of caspases as direct substrates of calcium-activated
proteases, calpains. Calpains cleave caspase-7 at sites distinct from those of the upstream …
execution of apoptosis can be sub-grouped according to the length of their prodomain. Long
prodomain caspases such as caspase-8 and caspase-9 are believed to act mainly as
upstream caspases to cleave downstream short prodomain caspases such as caspases-3
and-7. We report here the identification of caspases as direct substrates of calcium-activated
proteases, calpains. Calpains cleave caspase-7 at sites distinct from those of the upstream …