Inositol-1, 4, 5-triphosphate receptors mediate activity-induced synaptic Ca2+ signals in muscle fibers and Ca2+ overload in slow-channel syndrome

R Zayas, JS Groshong, CM Gomez - Cell calcium, 2007 - Elsevier
Strict control of calcium entry through excitatory synaptic receptors is important for shaping
synaptic responses, gene expression, and cell survival. Disruption of this control may lead to
pathological accumulation of Ca2+. The slow-channel congenital myasthenic syndrome
(SCS), due to mutations in muscle acetylcholine receptor (AChR), perturbs the kinetics of
synaptic currents, leading to post-synaptic Ca2+ accumulation. To understand the regulation
of calcium signaling at the neuromuscular junction (NMJ) and the etiology of Ca2+ overload …