[HTML][HTML] Protein kinase Cδ activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria
CL Murriel, E Churchill, K Inagaki, LI Szweda… - Journal of Biological …, 2004 - ASBMB
Heart attacks caused by occlusion of coronary arteries are often treated by mechanical or
enzymatic removal of the occlusion and reperfusion of the ischemic heart. It is now
recognized that reperfusion per se contributes to myocardial damage, and there is a great
interest in identifying the molecular basis of this damage. We recently showed that inhibiting
protein kinase Cδ (PKCδ) protects the heart from ischemia and reperfusion-induced
damage. Here, we demonstrate that PKCδ activity and mitochondrial translocation at the …
enzymatic removal of the occlusion and reperfusion of the ischemic heart. It is now
recognized that reperfusion per se contributes to myocardial damage, and there is a great
interest in identifying the molecular basis of this damage. We recently showed that inhibiting
protein kinase Cδ (PKCδ) protects the heart from ischemia and reperfusion-induced
damage. Here, we demonstrate that PKCδ activity and mitochondrial translocation at the …