[HTML][HTML] Prevalence and severity of pruritus and quality of life in patients with cutaneous T-cell lymphoma
A Wright, A Wijeratne, T Hung, W Gao… - Journal of pain and …, 2013 - Elsevier
Journal of pain and symptom management, 2013•Elsevier
CONTEXT: Cutaneous T-cell lymphoma (CTCL), although rare, is associated with a
significant symptom burden. Pruritus appears to be one of the most prominent and disturbing
symptoms. OBJECTIVES: To describe the prevalence and severity of pruritus and quality of
life (QOL) in patients with CTCL. METHODS: Patients with CTCL able to complete two
questionnaires were invited to complete a visual analogue scale for itch (VASitch) and the
Skindex-29. Prevalence of pruritus, mean score, and SD were estimated for the VASitch and …
significant symptom burden. Pruritus appears to be one of the most prominent and disturbing
symptoms. OBJECTIVES: To describe the prevalence and severity of pruritus and quality of
life (QOL) in patients with CTCL. METHODS: Patients with CTCL able to complete two
questionnaires were invited to complete a visual analogue scale for itch (VASitch) and the
Skindex-29. Prevalence of pruritus, mean score, and SD were estimated for the VASitch and …
CONTEXT
Cutaneous T-cell lymphoma (CTCL), although rare, is associated with a significant symptom burden. Pruritus appears to be one of the most prominent and disturbing symptoms.
OBJECTIVES
To describe the prevalence and severity of pruritus and quality of life (QOL) in patients with CTCL.
METHODS
Patients with CTCL able to complete two questionnaires were invited to complete a visual analogue scale for itch (VASitch) and the Skindex-29. Prevalence of pruritus, mean score, and SD were estimated for the VASitch and Skindex-29, and the Pearson's correlation coefficient was calculated to evaluate the relationship between severity of pruritus and QOL.
RESULTS
One hundred patients were recruited (mean [SD] age 57.9 [12.9] years, range 30–86 years). Eighty-eight percent reported pruritus in the preceding four weeks, 46% indicating that it was often or always a problem. The mean (SD) of VASitch (n=92) was 3.2 (3.2), range zero to 10. The mean (SD) total Skindex-29 score was 43.3 (27.7). More advanced disease stage was associated with poorer QOL. The Skindex-29 correlated strongly with the VASitch (Pearson's correlation coefficient=0.72, P<0.001).
CONCLUSION
All aspects of QOL are affected in CTCL. Pruritus is a common and troublesome symptom. A more advanced disease stage and more severe pruritus symptoms were associated with poorer QOL in this study.
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