[HTML][HTML] Targeting the transient receptor potential vanilloid type 1 (TRPV1) assembly domain attenuates inflammation-induced hypersensitivity
R Flynn, K Chapman, M Iftinca, R Aboushousha… - Journal of Biological …, 2014 - ASBMB
The transient receptor potential channel vanilloid type 1 (TRPV1) is a non-selective cation
channel expressed in sensory neurons of the dorsal root and trigeminal ganglia. TRPV1 is a
polymodal channel activated by noxious heat, capsaicin, and protons. As a sensor for
noxious stimuli, TRPV1 channel has been described as a key contributor to pain signaling.
To form a functional channel, TRPV1 subunits must assemble into tetramers, and several
studies have identified the TRPV1 C terminus as an essential element in subunit …
channel expressed in sensory neurons of the dorsal root and trigeminal ganglia. TRPV1 is a
polymodal channel activated by noxious heat, capsaicin, and protons. As a sensor for
noxious stimuli, TRPV1 channel has been described as a key contributor to pain signaling.
To form a functional channel, TRPV1 subunits must assemble into tetramers, and several
studies have identified the TRPV1 C terminus as an essential element in subunit …
