Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced …
P Honore, P Chandran, G Hernandez, DM Gauvin… - Pain, 2009 - Elsevier
Transient receptor potential vanilloid type 1 (TRPV1) is a ligand-gated ion channel that
functions as an integrator of multiple pain stimuli including heat, acid, capsaicin and a
variety of putative endogenous lipid ligands. TRPV1 antagonists have been shown to
decrease inflammatory pain in animal models and to produce limited hyperthermia at
analgesic doses. Here, we report that ABT-102, which is a potent and selective TRPV1
antagonist, is effective in blocking nociception in rodent models of inflammatory, post …
functions as an integrator of multiple pain stimuli including heat, acid, capsaicin and a
variety of putative endogenous lipid ligands. TRPV1 antagonists have been shown to
decrease inflammatory pain in animal models and to produce limited hyperthermia at
analgesic doses. Here, we report that ABT-102, which is a potent and selective TRPV1
antagonist, is effective in blocking nociception in rodent models of inflammatory, post …
