Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling
Y Zhang, W Wei, N Cheng, K Wang, B Li, X Jiang… - Hepatology, 2012 - journals.lww.com
Hepatitis C virus (HCV) infection usually induces chronic hepatic inflammation, which favors
the initiation and progression of hepatocellular carcinoma (HCC). Moreover, microRNA-155
(miR-155) plays an important role in regulating both inflammation and tumorigenesis.
However, little is known about whether and how miR-155 provides the link between
inflammation and cancer. In this study we found that miR-155 levels were markedly
increased in patients infected with HCV. MiR-155 transcription was regulated by nuclear …
the initiation and progression of hepatocellular carcinoma (HCC). Moreover, microRNA-155
(miR-155) plays an important role in regulating both inflammation and tumorigenesis.
However, little is known about whether and how miR-155 provides the link between
inflammation and cancer. In this study we found that miR-155 levels were markedly
increased in patients infected with HCV. MiR-155 transcription was regulated by nuclear …