Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo

MJ Wayner, DL Armstrong, CF Phelix, Y Oomura - Peptides, 2004 - Elsevier
Orexin-A (Hypocretin-1) has been localized in the posterior and lateral hypothalamic
perifornical region. Orexin containing axon terminals have been found in hypothalamic
nuclei and many other parts of the brain; for example, the hippocampus. Two types of orexin
receptors have been discovered. Orexin 1 type of receptors have been described and been
shown to be widely distributed in the rat brain including the hippocampus. Subsequently
Orexin-A was found to impair both water maze performance and hippocampal long term …